A case report of percutaneous mechanical thrombectomy with retrograde approach for the treatment of acute lower limb deep vein thrombosis: Is it safe?

Main Article Content

Gede Ari Mahendra
Syahrul Amirrullah
Putu Wisnu Arya Wardana

Keywords

Case report, deep vein thrombosis, percutaneous mechanical thrombectomy, retrograde approach

Abstract

Introduction: Deep vein thrombosis (DVT) is a type of venous thromboembolism. In recent years, an invasive approach with active thrombus removal with an antegrade approach has been suggested as an alternative to conventional medical treatment for acute DVT. Here, we report an uncommon Percutaneous mechanical thrombectomy (PMT) treatment for DVT with a retrograde approach.


Case description: A 28-year-old female presented with pain and swelling in the right leg for 9 days after a 10-hour flight. D-Dimer was elevated (3.24 ng/mL). Doppler USG revealed DVT involving the superficial femoral, popliteal, and peroneal veins, as well as superficial vein thrombosis at the saphenopopliteal junction and small saphenous vein. The patient received heparinization, followed by venogram, IVC filter implantation, and PMT via retrograde femoral vein access with a good clinical outcome. In this case, catheter access via antegrade failed, and retrograde via the right femoral vein was used. The retrograde venous approach also has several advantages, including a shorter procedure time due to the larger diameter of the proximal vein and fewer anatomical variants. There are also disadvantages, namely valve injury, as the direction of access is opposite to the direction of blood flow. IVC filter implantation is performed before thrombectomy with the aim of protection against PE caused in part by thrombus fragmentation during the thrombectomy.


Conclusion: Mechanical thrombectomy can be performed using a retrograde approach. The retrograde approach is safe and effective with no significant difference in technical success.

Abstract 80 | PDF Downloads 43

References

1. Kurtoglu T, Durmaz S, Dişçigil B. Endovascular and Surgical Treatment of Acute Deep Vein Thrombosis. Meandros Med Dent J [Internet]. 2020 Apr 1;21:1–11. Available from: 10.4274/meandros.galenos.2015.2366
2. Kakkos SK, Gohel M, Baekgaard N, Bauersachs R, Bellmunt-Montoya S, Black SA, et al. Editor’s Choice - European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis. Eur J Vasc Endovasc Surg [Internet]. 2021 Jan;61(1):9–82. Available from: 10.1016/j.ejvs.2020.09.023
3. Galanaud J-P, Kahn SR. Postthrombotic syndrome: a 2014 update. Curr Opin Cardiol [Internet]. 2014 Nov;29(6):514–9. Available from: 10.1097/HCO.0000000000000103
4. Waheed SM, Kudaravalli P, Hotwagner DT. Deep Venous Thrombosis. In Treasure Island (FL); 2025. Available from: https://pubmed.ncbi.nlm.nih.gov/29939530/
5. Stone J, Hangge P, Albadawi H, Wallace A, Shamoun F, Knuttien MG, et al. Deep vein thrombosis: pathogenesis, diagnosis, and medical management. Cardiovasc Diagn Ther [Internet]. 2017 Dec;7(Suppl 3):S276–84. Available from: 10.21037/cdt.2017.09.01
6. Shabbir T, Wade M, Das K, Nayyar R. Thrombectomy of a Complex Deep Vein Thrombosis: A Case Report. Cureus [Internet]. 2023 Jan;15(1):e33413. Available from: 10.7759/cureus.33413
7. Ortel TL, Neumann I, Ageno W, Beyth R, Clark NP, Cuker A, et al. American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism. Blood Adv [Internet]. 2020 Oct;4(19):4693–738. Available from: 10.1182/bloodadvances.2020001830
8. Shah KJ, Roy TL. Catheter-Directed Interventions for the Treatment of Lower Extremity Deep Vein Thrombosis. Life (Basel, Switzerland) [Internet]. 2022 Nov;12(12). Available from: 10.3390/life12121984
9. Andreoli JM, Thornburg BG, Hickey RM. Inferior Vena Cava Filter-Related Thrombus/Deep Vein Thrombosis: Data and Management. Semin Intervent Radiol [Internet]. 2016 Jun;33(2):101–4. Available from: 10.1055/s-0036-1581087
10. Bendix SD, Nolan R, Banipal S, Oppat WF. Posterior tibial vein approach to catheter-directed thrombolysis for iliofemoral deep venous thrombosis. J Vasc surgery Venous Lymphat Disord [Internet]. 2019 Sep;7(5):629–34. Available from: 10.1016/j.jvsv.2019.01.064
11. Yi K-H, Lee J-J, Hur H-W, Kim H-J. Anatomical consideration of deep calf veins: application to catheter-directed thrombolysis. Surg Radiol Anat [Internet]. 2021 Dec;43(12):2071–6. Available from: 10.1007/s00276-021-02821-7
12. Lee C-K, Chen Y-H, Lin M-S, Yeh C-F, Hung C-S, Kao H-L, et al. Retrograde Approach is as Effective and Safe as Antegrade Approach in Contemporary Percutaneous Coronary Intervention for Chronic Total Occlusion: A Taiwan Single-Center Registry Study. Acta Cardiol Sin. 2017 Jan;33(1):20–7.
13. Xuan T, Jianlong L, Jinyong L, Xiao L, Mi Z, Ruifeng B, et al. Antegrade and Retrograde Approaches with a Mechanical Thrombectomy Device for the Treatment of Acute Lower Limb Deep Vein Thrombosis. Ann Vasc Surg [Internet]. 2024 Nov;108:266–78. Available from: 10.1016/j.avsg.2024.04.014